Where to Inject GLP-1 Medications (Ozempic, Wegovy, Mounjaro, Semiglutides and more…)
According to Novo Nordisk, the recommended subcutaneous injection sites for GLP-1 medications include:
- Abdomen (at least 2 inches away from the belly button)
- Front of the thighs
- Upper arms (back of the arm, with assistance)
These sites are preferred because they offer a consistent layer of subcutaneous fat, which helps ensure proper absorption of the medication.
💡 Important: Rotate your injection site weekly to avoid tissue damage or buildup.
😖 Why Injections Might Get More Painful Over Time
As many GLP-1 users lose weight and reduce body fat, particularly in the abdominal area, injections can begin to feel more painful. This is a common side effect and doesn’t mean you’re doing something wrong.
We discuss this in detail in our related post: Do Injections Hurt More as You Lose Weight?
Using a device like the Digivibe by Suthe can help reduce discomfort during injections by applying high-frequency vibration to the injection site—stimulating surrounding nerves and dulling pain signals.
✅ Best Practices for GLP-1 Injections
- Clean the injection site with an alcohol swab
- Pinch a fold of skin (especially in the abdomen) to avoid injecting into muscle
- Inject at a 90-degree angle with the auto-injector or pen
- Hold the pen in place for 5-10 seconds to ensure full delivery
- Do not reuse needles (even if it seems wasteful)
🤔 What New GLP-1 Users Should Expect
If you’re just starting a GLP-1 medication like Ozempic, it’s normal to feel nervous about your first injection. Here’s what you should know:
- The pen is pre-filled and pre-measured
- You may feel a slight pinch or burning sensation
- Redness or mild soreness is normal after injecting
Most people report that the anxiety beforehand is worse than the injection itself—especially once they find a routine that works for them.
Want to make the experience more comfortable? Try our Digivibe Kit designed to ease the sting of subcutaneous injections.
📚 Additional Resources
- FDA Patient Info on Semaglutide (Ozempic)
- CDC Guide to Injection Safety
- Cleveland Clinic: What to Know About Injectable Weight Loss Medications
Conclusion: Mastering your injection routine can reduce side effects, improve comfort, and increase confidence. Choosing the right injection site, rotating regularly, and using tools like the Digivibe can make a huge difference in your weekly experience.
For more tips on reducing injection discomfort, check out our blog: How to Make Injections More Comfortable
Disclaimer: This article is for informational purposes only and is not a substitute for medical advice. Always consult your healthcare provider regarding proper injection technique and site selection.
